Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 176
interventional 114
Observational 58
Registry 4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 25
Drug|placebo 21
Other 21
Procedure 21
Device 13
Behavioral 2
Behavioral|Other 1
Biological 1
Biological|Drug 1
Biological|Other 1
Biological|placebo 1
Device|Other 1
Device|Procedure 1
Diagnostic Test 1
Drug|Other|Procedure 1
Drug|Radiation 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 33
NA 9
United Kingdom 8
China 7
Italy 7
Canada 5
France 4
Spain 4
United States|Canada 4
Austria 3
Brazil 3
Germany 3
Egypt 2
Japan 2
Korea, Republic of 2
Paraguay 2
Taiwan 2
Turkey 2
Australia 1
Belgium 1
Denmark 1
Hungary 1
Mexico 1
Poland 1
Switzerland 1
Thailand 1
United States|Australia|Belgium|Canada|New Zealand|Spain 1
United States|Austria|Germany|Israel 1
United States|France|Spain|United Kingdom 1
United States|Israel 1

Sites per Study

Site_count Study_Count
1 82
2 9
3 2
5 3
6 3
7 2
8 1
9 1
14 2
16 2
17 1
19 1
20 1
29 1
39 1
47 1
110 1

Phase

Phase Study_Count
N/A 59
Phase 2 26
Phase 1 6
Phase 1/Phase 2 6
Phase 4 6
Phase 3 5
Phase 2/Phase 3 4
Early Phase 1 2

Number of Arms

Number_of_Arms Count_of_Studies
1 18
2 74
3 12
4 1
5 1
7 1
NA 7

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 7 10.00000 3.00000 9.00 15.00000 43.00 84.0 50.0000
1st Qu. 9 25.00000 18.50000 27.25 40.00000 108.25 102.0 51.0000
Median 11 50.00000 33.50000 44.00 66.50000 221.50 192.0 72.0000
Mean 11 98.25862 33.66667 134.50 95.69231 252.50 329.6 174.3333
3rd Qu. 13 100.00000 52.25000 77.25 139.50000 365.75 270.0 137.2500
Max. 15 1100.00000 60.00000 600.00 400.00000 524.00 1000.0 649.0000

Trial Group Type

group_type Group_Count
Experimental 120
Active Comparator 47
Placebo Comparator 27
No Intervention 11
Other 11
NA 7
Sham Comparator 2

Intervention Model

intervention_model Study_Count
Parallel Assignment 77
Single Group Assignment 26
Crossover Assignment 7
Sequential Assignment 2
NA 2

Primary Purpose

primary_purpose Study_Count
Treatment 60
Prevention 29
Diagnostic 7
Supportive Care 6
Basic Science 5
Other 3
NA 3
Device Feasibility 1

Observational Studies

Studies by Country

Country Study_Count
United States 12
China 8
Italy 6
Canada 5
Spain 4
Taiwan 4
France 3
NA 3
Norway 2
United Kingdom 2
Argentina 1
Germany 1
Hungary 1
Italy|San Marino 1
Malaysia 1
Sierra Leone 1
Switzerland 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Netherlands|Spain|Sweden|Switzerland|United Kingdom 1
United States|Estonia|Germany|Italy|Lithuania|Netherlands|Norway|Slovenia 1

Sites per Study

Site_count Study_Count
1 47
2 3
3 1
4 2
5 1
8 1
15 1
19 1
58 1

Enrollment Metrics

Measure Observational
Min 5.0000
1st Qu 30.0000
Median 90.0000
Mean 517.9474
3rd Qu 200.0000
Max 10690.0000

Observation Model

observational_model Study_Count
Cohort 32
Case-Only 6
Case Control 6
Case-Control 5
NA 5
Other 4

Time Perspective

time_perspective Study_Count
Prospective 51
Cross-Sectional 3
Retrospective 3
NA 1

Registries

Studies by Country

Country Study_Count
Canada 1
Chile 1
Denmark 1
United States 1

Sites per Study

Site_count Study_Count
1 3
4 1

Enrollment Metrics

Measure Registries
Min 40.00
1st Qu 62.50
Median 105.00
Mean 241.75
3rd Qu 284.25
Max 717.00

Registry Model

observational_model Study_Count
Cohort 3
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 4

Follow-up

target_duration Study_Count
6 Months 2
28 Days 1
4 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04359290 Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS https://ClinicalTrials.gov/show/NCT04359290 Recruiting Philipps University Marburg Medical Center 2020-12-31
NCT03410511 Propylene Glycol/Glycerol Intake and Cardiorespiratory Function https://ClinicalTrials.gov/show/NCT03410511 Enrolling by invitation Université Libre de Bruxelles 2019-06-30
NCT03401463 Assesment of the Endotracheal Tube Cuff Pressure Values in ICU Pateints Before and After Training Seminar https://ClinicalTrials.gov/show/NCT03401463 Completed Jagiellonian University 2018-06-30
NCT04081012 N-acetyl Cysteine in Post-reperfusion Pulmonary Injury in Chronic Thromboembolic Pulmonary Hypertension. https://ClinicalTrials.gov/show/NCT04081012 Recruiting Instituto Nacional de Cardiologia Ignacio Chavez 2023-05-21
NCT03328117 A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury https://ClinicalTrials.gov/show/NCT03328117 Completed Exvastat Ltd. 2018-03-05
NCT03237364 Iraq- Afghanistan War Lung Injury Using 19F MRI (DIAL1001006) https://ClinicalTrials.gov/show/NCT03237364 Completed Duke University 2019-03-01
NCT03231735 Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT03231735 Recruiting University of Alabama at Birmingham 2021-07-31
NCT03202641 Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients https://ClinicalTrials.gov/show/NCT03202641 Recruiting Massachusetts General Hospital 2020-04-01
NCT03165760 Protective Mechanical Ventilation and Risk of Postoperative Complications in Abdominal Surgery https://ClinicalTrials.gov/show/NCT03165760 Completed Mongi Slim Hospital 2016-12-31
NCT03061617 Comparison of Different Ventilation Mode During One-lung Ventilation https://ClinicalTrials.gov/show/NCT03061617 Completed Shanghai Zhongshan Hospital 2016-09-30
NCT03056885 Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy https://ClinicalTrials.gov/show/NCT03056885 Completed University of Roma La Sapienza 2015-11-25
NCT03041428 Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO) https://ClinicalTrials.gov/show/NCT03041428 Active, not recruiting Fundación para la Investigación Biosanitaria del Principado de Asturias 2019-12-31
NCT03023670 Lung Protection and Pediatric Cardiac Surgery https://ClinicalTrials.gov/show/NCT03023670 Completed Assiut University 2018-03-31
NCT02918877 Anesthetics to Prevent Lung Injury in Cardiac Surgery https://ClinicalTrials.gov/show/NCT02918877 Active, not recruiting Beth Israel Deaconess Medical Center 2020-07-01
NCT02891837 L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects https://ClinicalTrials.gov/show/NCT02891837 Completed Asklepion Pharmaceuticals, LLC 2019-06-30
NCT02734654 Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage https://ClinicalTrials.gov/show/NCT02734654 Completed Instituto de Salud Carlos III 2011-02-28
NCT02670460 Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial https://ClinicalTrials.gov/show/NCT02670460 Completed Lungpacer Medical Inc. 2016-04-30
NCT02106975 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury https://ClinicalTrials.gov/show/NCT02106975 Completed Virginia Commonwealth University 2017-11-16
NCT02071277 APRV/BIPAP With Spontaneous Breathing on Lung Protection https://ClinicalTrials.gov/show/NCT02071277 Completed St. Michael’s Hospital, Toronto 2017-01-31
NCT01307085 Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection https://ClinicalTrials.gov/show/NCT01307085 Completed First Affiliated Hospital, Sun Yat-Sen University 2013-06-30
NCT01284452 Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) https://ClinicalTrials.gov/show/NCT01284452 Completed Mahidol University 2014-12-31
NCT01274481 Iloprost Effects on Gas Exchange and Pulmonary Mechanics https://ClinicalTrials.gov/show/NCT01274481 Completed University of Oklahoma 2012-07-31
NCT01272882 Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS https://ClinicalTrials.gov/show/NCT01272882 Completed Christiana Care Health Services 2011-03-31
NCT04369469 Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia https://ClinicalTrials.gov/show/NCT04369469 Recruiting Alexion Pharmaceuticals 2020-11-30
NCT01962818 High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance. https://ClinicalTrials.gov/show/NCT01962818 Active, not recruiting Rigshospitalet, Denmark 2018-07-31
NCT01883869 Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor https://ClinicalTrials.gov/show/NCT01883869 Completed University of Kentucky 2016-06-30
NCT01783821 LIPS-B: Lung Injury Prevention Study With Budesonide and Beta https://ClinicalTrials.gov/show/NCT01783821 Completed Mayo Clinic 2015-07-31
NCT04153487 Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury https://ClinicalTrials.gov/show/NCT04153487 Recruiting Damanhour University 2020-12-31
NCT02025075 Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade. https://ClinicalTrials.gov/show/NCT02025075 Completed Massachusetts General Hospital 2015-10-31
NCT01683669 Effect of Variable PSV in Acute Lung Injury: Part I and Part II https://ClinicalTrials.gov/show/NCT01683669 Completed University of Genova 2016-12-31
NCT01659307 The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury https://ClinicalTrials.gov/show/NCT01659307 Recruiting Belfast Health and Social Care Trust 2019-08-31
NCT01640990 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers https://ClinicalTrials.gov/show/NCT01640990 Completed GlaxoSmithKline 2011-12-09
NCT01627613 Study in Intensive Care Patients to Investigate the Clinical Effect of Repetitive Orally Inhaled Doses of AP301 on Alveolar Liquid Clearance in Acute Lung Injury https://ClinicalTrials.gov/show/NCT01627613 Completed Apeptico Forschung und Entwicklung GmbH 2014-05-31
NCT01597635 The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury https://ClinicalTrials.gov/show/NCT01597635 Completed GlaxoSmithKline 2014-10-01
NCT01581229 Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury https://ClinicalTrials.gov/show/NCT01581229 Completed Beijing Hospital 2016-12-31
NCT01552070 Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS) https://ClinicalTrials.gov/show/NCT01552070 Completed Chang Gung Memorial Hospital 2013-05-31
NCT01532024 Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs https://ClinicalTrials.gov/show/NCT01532024 Completed University of Edinburgh 2016-09-02
NCT01514331 Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation https://ClinicalTrials.gov/show/NCT01514331 Completed Gazi University 2013-11-30
NCT01513018 Effects of High and Low Tidal Volumes on Arterial Oxygenation and Pulmonary Shunt During One-Lung Ventilation https://ClinicalTrials.gov/show/NCT01513018 Completed The Cleveland Clinic 2009-09-30
NCT01504893 Protective Ventilation With Low Tidal Volume Versus an Ultraprotective Ventilatory Strategy for One-lung Ventilation in Patients Undergoing Thoracic Anesthesia. https://ClinicalTrials.gov/show/NCT01504893 Completed Azienda Ospedaliera S. Maria della Misericordia 2016-08-31
NCT01504867 LIPS-A: Lung Injury Prevention Study With Aspirin https://ClinicalTrials.gov/show/NCT01504867 Completed Mayo Clinic 2015-09-30
NCT01502332 Intensive Alveolar Recruitment Protocol After Cardiac Surgery https://ClinicalTrials.gov/show/NCT01502332 Completed University of Sao Paulo 2014-02-28
NCT01474863 Citrulline in Severe Sepsis https://ClinicalTrials.gov/show/NCT01474863 Completed Vanderbilt University Medical Center 2016-03-31
NCT01438853 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT01438853 Completed Altor BioScience 2006-07-31
NCT01434121 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis https://ClinicalTrials.gov/show/NCT01434121 Completed Virginia Commonwealth University 2012-09-30
NCT01427621 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery https://ClinicalTrials.gov/show/NCT01427621 Completed Yonsei University 2010-11-30
NCT01344239 Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair https://ClinicalTrials.gov/show/NCT01344239 Completed First Affiliated Hospital, Sun Yat-Sen University 2011-05-31
NCT01335932 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure https://ClinicalTrials.gov/show/NCT01335932 Completed Fred Hutchinson Cancer Research Center 2016-06-17
NCT01320384 Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study) https://ClinicalTrials.gov/show/NCT01320384 Completed Poitiers University Hospital 2013-07-31
NCT04434001 ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery https://ClinicalTrials.gov/show/NCT04434001 Recruiting IRCCS Policlinico S. Donato 2020-08-10
NCT04412057 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury https://ClinicalTrials.gov/show/NCT04412057 Recruiting Cerecor Inc 2020-10-31
NCT04402866 TD-0903 for ALI Associated With COVID-19 https://ClinicalTrials.gov/show/NCT04402866 Recruiting Theravance Biopharma 2020-10-31
NCT04397510 Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury https://ClinicalTrials.gov/show/NCT04397510 Enrolling by invitation Frederick Health 2020-12-31
NCT04389840 Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure https://ClinicalTrials.gov/show/NCT04389840 Recruiting Chimerix 2021-02-28
NCT04375397 Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury https://ClinicalTrials.gov/show/NCT04375397 Recruiting AbbVie 2020-08-13
NCT04350736 First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19 https://ClinicalTrials.gov/show/NCT04350736 Recruiting Theravance Biopharma 2020-06-30
NCT04341038 Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury https://ClinicalTrials.gov/show/NCT04341038 Recruiting Hospital Universitari de Bellvitge 2020-06-01
NCT04331613 Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS https://ClinicalTrials.gov/show/NCT04331613 Recruiting Chinese Academy of Sciences 2020-12-31
NCT04289324 Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants https://ClinicalTrials.gov/show/NCT04289324 Recruiting Medical University of Vienna 2022-06-30
NCT04133740 Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study https://ClinicalTrials.gov/show/NCT04133740 Active, not recruiting Aalborg University Hospital 2019-07-15
NCT03978845 Phrenic Nerve Block to Mitigate Self-inflicted Lung Injury https://ClinicalTrials.gov/show/NCT03978845 Recruiting University of Sao Paulo General Hospital 2019-12-31
NCT03960853 Effects of Different Ventilation Patterns on Lung Injury https://ClinicalTrials.gov/show/NCT03960853 Recruiting Sixth Affiliated Hospital, Sun Yat-sen University 2021-12-31
NCT03951064 Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon https://ClinicalTrials.gov/show/NCT03951064 Enrolling by invitation University of North Carolina, Chapel Hill 2021-06-30
NCT03905837 Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery https://ClinicalTrials.gov/show/NCT03905837 Recruiting Hospital General Universitario Gregorio Marañon 2021-05-28
NCT03902509 A Study About Safety and Efficacy of Pirfenidone to Treat Grade 2 or Grade3 Radiation-induced Lung Injury. https://ClinicalTrials.gov/show/NCT03902509 Recruiting Beijing Continent Pharmaceutical Co, Ltd. 2021-04-30
NCT03817918 A New Ultrasonographic Tool to Assess Pulmonary Strain in Patients Under One-lung Ventilation. https://ClinicalTrials.gov/show/NCT03817918 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2019-05-17
NCT03764319 Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and VV-ECMO https://ClinicalTrials.gov/show/NCT03764319 Recruiting Medical University of Vienna 2020-05-06
NCT03753022 Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery https://ClinicalTrials.gov/show/NCT03753022 Active, not recruiting Federal University of São Paulo 2019-12-31
NCT03719365 Driving Pressure Variation: NAVA vs PSV https://ClinicalTrials.gov/show/NCT03719365 Recruiting Azienda Ospedaliero Universitaria Maggiore della Carita 2019-12-01
NCT03659552 Percutaneous Temporary Placement of a Transvenous Phrenic Nerve Stimulator for Diaphragm Pacing Using Jugular Access https://ClinicalTrials.gov/show/NCT03659552 Completed Lungpacer Medical Inc. 2018-06-30
NCT03651817 Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg https://ClinicalTrials.gov/show/NCT03651817 Completed Kocaeli University 2019-11-20
NCT03637530 a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries https://ClinicalTrials.gov/show/NCT03637530 Active, not recruiting All India Institute of Medical Sciences, Rishikesh 2018-05-31
NCT03612583 Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work https://ClinicalTrials.gov/show/NCT03612583 Recruiting University Health Network, Toronto 2020-10-30
NCT03525691 Enhanced Lung Protective Ventilation With ECCO2R During ARDS https://ClinicalTrials.gov/show/NCT03525691 Recruiting Hôpital Européen Marseille 2020-12-30
NCT03464071 Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation https://ClinicalTrials.gov/show/NCT03464071 Recruiting Hospital de Clinicas de Porto Alegre 2019-09-10
NCT03437499 Adrenomedullin Changes After Sustained Inflation or Positive Pressure Ventilation at Birth https://ClinicalTrials.gov/show/NCT03437499 Completed Vittore Buzzi Children’s Hospital 2014-10-31
NCT03435913 Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery https://ClinicalTrials.gov/show/NCT03435913 Completed Hospital Universitario La Fe 2018-11-21
NCT01260259 Seattle Cardiorenal Remote Ischemic Preconditioning Trial https://ClinicalTrials.gov/show/NCT01260259 Completed Seattle Children’s Hospital 2013-08-31
NCT01194895 A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery https://ClinicalTrials.gov/show/NCT01194895 Completed Shanghai Zhongshan Hospital 2013-01-31
NCT01170845 Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy https://ClinicalTrials.gov/show/NCT01170845 Completed Yokohama City University Medical Center 2009-03-31
NCT01150864 Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial https://ClinicalTrials.gov/show/NCT01150864 Completed Università degli Studi dell’Insubria 2015-03-31
NCT01144585 Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass https://ClinicalTrials.gov/show/NCT01144585 Completed Seoul National University Hospital 2010-11-30
NCT01114009 Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients https://ClinicalTrials.gov/show/NCT01114009 Completed Chi Mei Medical Hospital 2011-12-31
NCT01050699 Sleep Intervention During Acute Lung Injury https://ClinicalTrials.gov/show/NCT01050699 Active, not recruiting University of Arizona 2019-03-31
NCT00999713 CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients https://ClinicalTrials.gov/show/NCT00999713 Completed Milton S. Hershey Medical Center 2015-09-30
NCT00996840 SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS https://ClinicalTrials.gov/show/NCT00996840 Completed GlaxoSmithKline 2013-02-09
NCT00963066 NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury https://ClinicalTrials.gov/show/NCT00963066 Completed University Hospital, Caen 2009-11-30
NCT00879606 Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT00879606 Completed Altor BioScience 2012-10-31
NCT00852605 Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment https://ClinicalTrials.gov/show/NCT00852605 Completed Technische Universität Dresden 2005-08-31
NCT00830284 Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury https://ClinicalTrials.gov/show/NCT00830284 Completed Boston Children’s Hospital 2012-12-31
NCT00883948 Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study) https://ClinicalTrials.gov/show/NCT00883948 Completed National Heart, Lung, and Blood Institute (NHLBI) 2011-03-31
NCT03092557 A New Ultrasonographic Tool to Assess Regional Pulmonary Strain https://ClinicalTrials.gov/show/NCT03092557 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2017-10-26
NCT02978885 Imaging of Peri-operative (periOP) Lung Injury https://ClinicalTrials.gov/show/NCT02978885 Recruiting Columbia University 2020-09-30
NCT04351243 A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE). https://ClinicalTrials.gov/show/NCT04351243 Recruiting Kinevant Sciences GmbH 2020-10-31
NCT04311697 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure https://ClinicalTrials.gov/show/NCT04311697 Recruiting NeuroRx, Inc. 2020-08-31
NCT00789685 Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II https://ClinicalTrials.gov/show/NCT00789685 Completed Faron Pharmaceuticals Ltd 2011-09-30
NCT00786292 Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury https://ClinicalTrials.gov/show/NCT00786292 Completed Technische Universität Dresden 2012-09-30
NCT00747045 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients https://ClinicalTrials.gov/show/NCT00747045 Completed University of California, San Diego 2011-03-31
NCT00655928 Modulation of Lung Injury Complicating Lung Resection https://ClinicalTrials.gov/show/NCT00655928 Completed Imperial College London 2009-07-31
NCT00624650 Hemodynamics and Extravascular Lung Water in Acute Lung Injury https://ClinicalTrials.gov/show/NCT00624650 Completed Oregon Health and Science University 2011-01-31
NCT00568659 The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position https://ClinicalTrials.gov/show/NCT00568659 Completed Policlinico Hospital 2010-11-30
NCT00559130 Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis https://ClinicalTrials.gov/show/NCT00559130 Completed MedaSorb Technologies, Inc 2011-04-30
NCT00538161 Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient https://ClinicalTrials.gov/show/NCT00538161 Completed Beth Israel Deaconess Medical Center 2009-10-31
NCT00498251 Prevention of Lung Edema After Thoracic Surgery https://ClinicalTrials.gov/show/NCT00498251 Completed University Hospital, Geneva NA
NCT00355875 The Effect of Oxygen Exposure During Newborn Resuscitation on Lung Injury https://ClinicalTrials.gov/show/NCT00355875 Completed University of Calgary NA
NCT00351533 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) https://ClinicalTrials.gov/show/NCT00351533 Completed University of Washington 2009-01-31
NCT00290602 Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT00290602 Completed National Cancer Center, Korea NA
NCT00219375 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan https://ClinicalTrials.gov/show/NCT00219375 Completed Ono Pharmaceutical Co. Ltd 2007-07-31
NCT00188058 Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT00188058 Completed University Hospital, Angers 2006-01-31
NCT00143468 The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients https://ClinicalTrials.gov/show/NCT00143468 Completed Policlinico Hospital 2007-03-31
NCT00133614 Prone Positioning in Pediatric Acute Lung Injury https://ClinicalTrials.gov/show/NCT00133614 Completed National Institute of Nursing Research (NINR) NA
NCT00127491 Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury https://ClinicalTrials.gov/show/NCT00127491 Completed Beth Israel Deaconess Medical Center 2007-08-31
NCT00036062 A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury https://ClinicalTrials.gov/show/NCT00036062 Completed Eli Lilly and Company NA
NCT00141726 Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant https://ClinicalTrials.gov/show/NCT00141726 Completed University of Michigan Rogel Cancer Center 2008-07-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03405779 A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU https://ClinicalTrials.gov/show/NCT03405779 Recruiting Centre hospitalier de l’Université de Montréal (CHUM) 2019-12-31
NCT03317431 the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury https://ClinicalTrials.gov/show/NCT03317431 Completed Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 2017-10-22
NCT03315702 Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins https://ClinicalTrials.gov/show/NCT03315702 Completed Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 2017-10-15
NCT03135691 Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA https://ClinicalTrials.gov/show/NCT03135691 Recruiting Ohio State University 2020-12-31
NCT03076983 Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time https://ClinicalTrials.gov/show/NCT03076983 Completed Drägerwerk AG & Co. KGaA 2018-04-12
NCT02977676 Ventilator-Associated Events: Prevalence, Outcome and Preventability https://ClinicalTrials.gov/show/NCT02977676 Completed Hospital Sao Domingos 2016-01-31
NCT02732041 Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT02732041 Completed Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno 2018-11-22
NCT02475694 Acute Lung Injury After Cardiac Surgery: Pathogenesis https://ClinicalTrials.gov/show/NCT02475694 Completed Aalborg University Hospital 2009-03-31
NCT02299921 Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure https://ClinicalTrials.gov/show/NCT02299921 Active, not recruiting University of Colorado, Denver 2022-02-28
NCT02247700 Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography https://ClinicalTrials.gov/show/NCT02247700 Completed Boston Children’s Hospital 2018-11-04
NCT02201446 The Role of Circulating Soluble CD74 in Acute Lung Injury https://ClinicalTrials.gov/show/NCT02201446 Completed Changhai Hospital 2014-11-30
NCT02174029 Serial Daily Diaphragm Ultrasounds in Ventilated Patients https://ClinicalTrials.gov/show/NCT02174029 Completed Fraser Health 2014-08-31
NCT02083393 Changes of Dendritic Cells in Acute Lung Injury https://ClinicalTrials.gov/show/NCT02083393 Completed Southeast University, China 2014-12-31
NCT01270295 Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE). https://ClinicalTrials.gov/show/NCT01270295 Completed University Hospital, Clermont-Ferrand 2013-01-31
NCT04262440 The Effect of Caloric Supplement in the Clinical Outcomes in Acute Lung Injury Patients https://ClinicalTrials.gov/show/NCT04262440 Recruiting Taichung Veterans General Hospital 2022-12-31
NCT01628523 Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study https://ClinicalTrials.gov/show/NCT01628523 Completed Washington University School of Medicine 2013-08-31
NCT01601223 Local Assessment of Ventilatory Management During General Anesthesia for Surgery https://ClinicalTrials.gov/show/NCT01601223 Completed European Society of Anaesthesiology 2013-05-31
NCT01486342 PET Imaging in Patients at Risk for Acute Lung Injury https://ClinicalTrials.gov/show/NCT01486342 Completed Washington University School of Medicine 2012-10-31
NCT01322295 Human Bronchial Microdialysis in Open Aortic Aneurysm Repair https://ClinicalTrials.gov/show/NCT01322295 Completed Norwegian University of Science and Technology 2011-11-30
NCT01321398 Transpulmonary Pressure Gradients in High Frequency Oscillation https://ClinicalTrials.gov/show/NCT01321398 Completed University of British Columbia 2011-07-31
NCT04395482 Lung CT Scan Analysis of SARS-CoV2 Induced Lung Injury https://ClinicalTrials.gov/show/NCT04395482 Recruiting University of Milano Bicocca 2020-06-15
NCT04046380 A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies https://ClinicalTrials.gov/show/NCT04046380 Recruiting Changhua Christian Hospital 2021-06-30
NCT04030078 A Central and Eastern European Survey On PEEP Titration and Alveolar Recruitment Manoeuvres During Surgery https://ClinicalTrials.gov/show/NCT04030078 Completed Péterfy Sándor Hospital 2019-09-30
NCT03947476 Extrapulmonary Lung Protection Strategy for Patients With Mechanical Ventilation https://ClinicalTrials.gov/show/NCT03947476 Recruiting Shanghai Zhongshan Hospital 2021-08-01
NCT03945409 New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure https://ClinicalTrials.gov/show/NCT03945409 Recruiting University of Milan 2020-03-31
NCT03937947 Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study https://ClinicalTrials.gov/show/NCT03937947 Recruiting NHS Lothian 2020-10-31
NCT03924206 Hazardous Surgical Smoke: Risk Assessment and Evaluation of a New Smoke Extractor System in the Surgical Unit https://ClinicalTrials.gov/show/NCT03924206 Completed University Hospital Inselspital, Berne 2019-09-09
NCT03828630 Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients https://ClinicalTrials.gov/show/NCT03828630 Completed Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 2019-02-27
NCT03766204 The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury https://ClinicalTrials.gov/show/NCT03766204 Recruiting Changhai Hospital 2023-12-31
NCT03746236 Transpulmonary Pressure Under Stressing Conditions https://ClinicalTrials.gov/show/NCT03746236 Recruiting Regina Elena Cancer Institute 2019-12-30
NCT03654352 The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS) https://ClinicalTrials.gov/show/NCT03654352 Recruiting University of Kentucky 2020-12-31
NCT03431129 Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation https://ClinicalTrials.gov/show/NCT03431129 Recruiting The Hospital for Sick Children 2020-11-30
NCT01187004 Extracardiac Complications After Cardiac Surgery https://ClinicalTrials.gov/show/NCT01187004 Completed University of Turin, Italy 2008-12-31
NCT01159392 Alveolar Recruitment in Brain Injury https://ClinicalTrials.gov/show/NCT01159392 Completed Hospital Clinic of Barcelona NA
NCT01142544 Incidence of Acute Lung Injury in Children https://ClinicalTrials.gov/show/NCT01142544 Completed Dr. Negrin University Hospital 2011-02-28
NCT01105663 Pharmacologic Impact on Sedation Assessments https://ClinicalTrials.gov/show/NCT01105663 Completed Children’s Hospital of Philadelphia 2013-12-31
NCT01089400 Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage https://ClinicalTrials.gov/show/NCT01089400 Completed Institut National de la Santé Et de la Recherche Médicale, France NA
NCT01078831 Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy https://ClinicalTrials.gov/show/NCT01078831 Completed Oslo University Hospital 2010-04-30
NCT00980915 Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury https://ClinicalTrials.gov/show/NCT00980915 Active, not recruiting Mayo Clinic 2020-12-31
NCT00889772 Lung Injury Prediction Study https://ClinicalTrials.gov/show/NCT00889772 Completed Mayo Clinic 2010-02-28
NCT00826072 Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery https://ClinicalTrials.gov/show/NCT00826072 Completed Changhai Hospital 2008-11-30
NCT00825357 Biological Markers to Identify Early Sepsis and Acute Lung Injury https://ClinicalTrials.gov/show/NCT00825357 Completed Chimei Medical Center 2011-08-31
NCT04449081 Knowledge, Attitude and Practice of Dental Students About COVID-19 https://ClinicalTrials.gov/show/NCT04449081 Completed Melaka Manipal Medical College 2020-06-10
NCT00811629 Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients https://ClinicalTrials.gov/show/NCT00811629 Completed University Hospital, Clermont-Ferrand 2009-07-31
NCT01922557 Thoracic Fluid Content and Acute Lung Injury https://ClinicalTrials.gov/show/NCT01922557 Completed National Taiwan University Hospital 2011-01-31
NCT03709199 Long Term Follow up of Children Enrolled in the REDvent Study https://ClinicalTrials.gov/show/NCT03709199 Recruiting Children’s Hospital Los Angeles 2023-01-01
NCT02739438 The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction https://ClinicalTrials.gov/show/NCT02739438 Recruiting Queen’s University, Belfast 2019-12-31
NCT02549222 A Open Label, Post Marketing Surveillance Study Following Transfusion of INTERCEPT Platelet Components https://ClinicalTrials.gov/show/NCT02549222 Enrolling by invitation Cerus Corporation 2020-09-30
NCT00736892 Incidence of Acute Lung Injury: The Alien Study https://ClinicalTrials.gov/show/NCT00736892 Completed Villar, Jesus, M.D. 2010-03-31
NCT00682942 How to Predict Lung Recruitment at the Bedside in Patients Affected by Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) https://ClinicalTrials.gov/show/NCT00682942 Completed Policlinico Hospital 2011-06-30
NCT00673517 The Effect of High Frequency Oscillation on Biological Markers of Lung Injury https://ClinicalTrials.gov/show/NCT00673517 Completed St. Michael’s Hospital, Toronto 2008-11-30
NCT00659152 Morphofunctional Lung Analysis by Positron Emission Tomography https://ClinicalTrials.gov/show/NCT00659152 Completed Policlinico Hospital 2013-12-31
NCT00521625 Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury https://ClinicalTrials.gov/show/NCT00521625 Completed St. Justine’s Hospital NA
NCT00435110 Effects of PEEP and FIO2 in ALI and ARDS https://ClinicalTrials.gov/show/NCT00435110 Completed Instituto Canario de Investigacion Biomedica NA
NCT00819871 Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery https://ClinicalTrials.gov/show/NCT00819871 Completed Changhai Hospital 2008-10-31
NCT00300248 Long-Term Results in Mechanically Ventilated Individuals With Acute Lung Injury/Acute Respiratory Distress Syndrome https://ClinicalTrials.gov/show/NCT00300248 Completed Johns Hopkins University 2012-10-31
NCT00258518 Respiratory Mechanics and Pleural Effusion https://ClinicalTrials.gov/show/NCT00258518 Completed Policlinico Hospital 2011-06-30
NCT00234767 Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS) https://ClinicalTrials.gov/show/NCT00234767 Completed University of Pittsburgh 2007-08-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02613377 Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children https://ClinicalTrials.gov/show/NCT02613377 Active, not recruiting St. Justine’s Hospital 2020-01-31
NCT02320539 MicroRNA Diagnostics in Subarachnoid Hemorrhage 2 https://ClinicalTrials.gov/show/NCT02320539 Completed Rigshospitalet, Denmark 2015-05-31
NCT03581006 Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment, and Dietary Intervention https://ClinicalTrials.gov/show/NCT03581006 Recruiting NYU Langone Health 2021-09-30
NCT03513809 Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients https://ClinicalTrials.gov/show/NCT03513809 Recruiting Pontificia Universidad Catolica de Chile 2021-06-08