lung injury

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	176
interventional	114
Observational	58
Registry	4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	25
Drug|placebo	21
Other	21
Procedure	21
Device	13
Behavioral	2
Behavioral|Other	1
Biological	1
Biological|Drug	1
Biological|Other	1
Biological|placebo	1
Device|Other	1
Device|Procedure	1
Diagnostic Test	1
Drug|Other|Procedure	1
Drug|Radiation	1
Other|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	33
NA	9
United Kingdom	8
China	7
Italy	7
Canada	5
France	4
Spain	4
United States|Canada	4
Austria	3
Brazil	3
Germany	3
Egypt	2
Japan	2
Korea, Republic of	2
Paraguay	2
Taiwan	2
Turkey	2
Australia	1
Belgium	1
Denmark	1
Hungary	1
Mexico	1
Poland	1
Switzerland	1
Thailand	1
United States|Australia|Belgium|Canada|New Zealand|Spain	1
United States|Austria|Germany|Israel	1
United States|France|Spain|United Kingdom	1
United States|Israel	1

Sites per Study

Site_count	Study_Count
1	82
2	9
3	2
5	3
6	3
7	2
8	1
9	1
14	2
16	2
17	1
19	1
20	1
29	1
39	1
47	1
110	1

Phase

Phase	Study_Count
N/A	59
Phase 2	26
Phase 1	6
Phase 1/Phase 2	6
Phase 4	6
Phase 3	5
Phase 2/Phase 3	4
Early Phase 1	2

Number of Arms

Number_of_Arms	Count_of_Studies
1	18
2	74
3	12
4	1
5	1
7	1
NA	7

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	7	10.00000	3.00000	9.00	15.00000	43.00	84.0	50.0000
1st Qu.	9	25.00000	18.50000	27.25	40.00000	108.25	102.0	51.0000
Median	11	50.00000	33.50000	44.00	66.50000	221.50	192.0	72.0000
Mean	11	98.25862	33.66667	134.50	95.69231	252.50	329.6	174.3333
3rd Qu.	13	100.00000	52.25000	77.25	139.50000	365.75	270.0	137.2500
Max.	15	1100.00000	60.00000	600.00	400.00000	524.00	1000.0	649.0000

Trial Group Type

group_type	Group_Count
Experimental	120
Active Comparator	47
Placebo Comparator	27
No Intervention	11
Other	11
NA	7
Sham Comparator	2

Intervention Model

intervention_model	Study_Count
Parallel Assignment	77
Single Group Assignment	26
Crossover Assignment	7
Sequential Assignment	2
NA	2

Primary Purpose

primary_purpose	Study_Count
Treatment	60
Prevention	29
Diagnostic	7
Supportive Care	6
Basic Science	5
Other	3
NA	3
Device Feasibility	1

Observational Studies

Studies by Country

Country	Study_Count
United States	12
China	8
Italy	6
Canada	5
Spain	4
Taiwan	4
France	3
NA	3
Norway	2
United Kingdom	2
Argentina	1
Germany	1
Hungary	1
Italy|San Marino	1
Malaysia	1
Sierra Leone	1
Switzerland	1
United States|Austria|Belgium|Canada|France|Germany|Italy|Netherlands|Spain|Sweden|Switzerland|United Kingdom	1
United States|Estonia|Germany|Italy|Lithuania|Netherlands|Norway|Slovenia	1

Sites per Study

Site_count	Study_Count
1	47
2	3
3	1
4	2
5	1
8	1
15	1
19	1
58	1

Enrollment Metrics

Measure	Observational
Min	5.0000
1st Qu	30.0000
Median	90.0000
Mean	517.9474
3rd Qu	200.0000
Max	10690.0000

Observation Model

observational_model	Study_Count
Cohort	32
Case-Only	6
Case Control	6
Case-Control	5
NA	5
Other	4

Time Perspective

time_perspective	Study_Count
Prospective	51
Cross-Sectional	3
Retrospective	3
NA	1

Registries

Studies by Country

Country	Study_Count
Canada	1
Chile	1
Denmark	1
United States	1

Sites per Study

Site_count	Study_Count
1	3
4	1

Enrollment Metrics

Measure	Registries
Min	40.00
1st Qu	62.50
Median	105.00
Mean	241.75
3rd Qu	284.25
Max	717.00

Registry Model

observational_model	Study_Count
Cohort	3
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	4

Follow-up

target_duration	Study_Count
6 Months	2
28 Days	1
4 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04359290	Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS	https://ClinicalTrials.gov/show/NCT04359290	Recruiting	Philipps University Marburg Medical Center	2020-12-31
NCT03410511	Propylene Glycol/Glycerol Intake and Cardiorespiratory Function	https://ClinicalTrials.gov/show/NCT03410511	Enrolling by invitation	Université Libre de Bruxelles	2019-06-30
NCT03401463	Assesment of the Endotracheal Tube Cuff Pressure Values in ICU Pateints Before and After Training Seminar	https://ClinicalTrials.gov/show/NCT03401463	Completed	Jagiellonian University	2018-06-30
NCT04081012	N-acetyl Cysteine in Post-reperfusion Pulmonary Injury in Chronic Thromboembolic Pulmonary Hypertension.	https://ClinicalTrials.gov/show/NCT04081012	Recruiting	Instituto Nacional de Cardiologia Ignacio Chavez	2023-05-21
NCT03328117	A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury	https://ClinicalTrials.gov/show/NCT03328117	Completed	Exvastat Ltd.	2018-03-05
NCT03237364	Iraq- Afghanistan War Lung Injury Using 19F MRI (DIAL1001006)	https://ClinicalTrials.gov/show/NCT03237364	Completed	Duke University	2019-03-01
NCT03231735	Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT03231735	Recruiting	University of Alabama at Birmingham	2021-07-31
NCT03202641	Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients	https://ClinicalTrials.gov/show/NCT03202641	Recruiting	Massachusetts General Hospital	2020-04-01
NCT03165760	Protective Mechanical Ventilation and Risk of Postoperative Complications in Abdominal Surgery	https://ClinicalTrials.gov/show/NCT03165760	Completed	Mongi Slim Hospital	2016-12-31
NCT03061617	Comparison of Different Ventilation Mode During One-lung Ventilation	https://ClinicalTrials.gov/show/NCT03061617	Completed	Shanghai Zhongshan Hospital	2016-09-30
NCT03056885	Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy	https://ClinicalTrials.gov/show/NCT03056885	Completed	University of Roma La Sapienza	2015-11-25
NCT03041428	Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)	https://ClinicalTrials.gov/show/NCT03041428	Active, not recruiting	Fundación para la Investigación Biosanitaria del Principado de Asturias	2019-12-31
NCT03023670	Lung Protection and Pediatric Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03023670	Completed	Assiut University	2018-03-31
NCT02918877	Anesthetics to Prevent Lung Injury in Cardiac Surgery	https://ClinicalTrials.gov/show/NCT02918877	Active, not recruiting	Beth Israel Deaconess Medical Center	2020-07-01
NCT02891837	L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects	https://ClinicalTrials.gov/show/NCT02891837	Completed	Asklepion Pharmaceuticals, LLC	2019-06-30
NCT02734654	Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage	https://ClinicalTrials.gov/show/NCT02734654	Completed	Instituto de Salud Carlos III	2011-02-28
NCT02670460	Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial	https://ClinicalTrials.gov/show/NCT02670460	Completed	Lungpacer Medical Inc.	2016-04-30
NCT02106975	Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury	https://ClinicalTrials.gov/show/NCT02106975	Completed	Virginia Commonwealth University	2017-11-16
NCT02071277	APRV/BIPAP With Spontaneous Breathing on Lung Protection	https://ClinicalTrials.gov/show/NCT02071277	Completed	St. Michael’s Hospital, Toronto	2017-01-31
NCT01307085	Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection	https://ClinicalTrials.gov/show/NCT01307085	Completed	First Affiliated Hospital, Sun Yat-Sen University	2013-06-30
NCT01284452	Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT01284452	Completed	Mahidol University	2014-12-31
NCT01274481	Iloprost Effects on Gas Exchange and Pulmonary Mechanics	https://ClinicalTrials.gov/show/NCT01274481	Completed	University of Oklahoma	2012-07-31
NCT01272882	Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS	https://ClinicalTrials.gov/show/NCT01272882	Completed	Christiana Care Health Services	2011-03-31
NCT04369469	Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia	https://ClinicalTrials.gov/show/NCT04369469	Recruiting	Alexion Pharmaceuticals	2020-11-30
NCT01962818	High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance.	https://ClinicalTrials.gov/show/NCT01962818	Active, not recruiting	Rigshospitalet, Denmark	2018-07-31
NCT01883869	Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor	https://ClinicalTrials.gov/show/NCT01883869	Completed	University of Kentucky	2016-06-30
NCT01783821	LIPS-B: Lung Injury Prevention Study With Budesonide and Beta	https://ClinicalTrials.gov/show/NCT01783821	Completed	Mayo Clinic	2015-07-31
NCT04153487	Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury	https://ClinicalTrials.gov/show/NCT04153487	Recruiting	Damanhour University	2020-12-31
NCT02025075	Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.	https://ClinicalTrials.gov/show/NCT02025075	Completed	Massachusetts General Hospital	2015-10-31
NCT01683669	Effect of Variable PSV in Acute Lung Injury: Part I and Part II	https://ClinicalTrials.gov/show/NCT01683669	Completed	University of Genova	2016-12-31
NCT01659307	The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01659307	Recruiting	Belfast Health and Social Care Trust	2019-08-31
NCT01640990	A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT01640990	Completed	GlaxoSmithKline	2011-12-09
NCT01627613	Study in Intensive Care Patients to Investigate the Clinical Effect of Repetitive Orally Inhaled Doses of AP301 on Alveolar Liquid Clearance in Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01627613	Completed	Apeptico Forschung und Entwicklung GmbH	2014-05-31
NCT01597635	The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01597635	Completed	GlaxoSmithKline	2014-10-01
NCT01581229	Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01581229	Completed	Beijing Hospital	2016-12-31
NCT01552070	Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT01552070	Completed	Chang Gung Memorial Hospital	2013-05-31
NCT01532024	Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs	https://ClinicalTrials.gov/show/NCT01532024	Completed	University of Edinburgh	2016-09-02
NCT01514331	Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation	https://ClinicalTrials.gov/show/NCT01514331	Completed	Gazi University	2013-11-30
NCT01513018	Effects of High and Low Tidal Volumes on Arterial Oxygenation and Pulmonary Shunt During One-Lung Ventilation	https://ClinicalTrials.gov/show/NCT01513018	Completed	The Cleveland Clinic	2009-09-30
NCT01504893	Protective Ventilation With Low Tidal Volume Versus an Ultraprotective Ventilatory Strategy for One-lung Ventilation in Patients Undergoing Thoracic Anesthesia.	https://ClinicalTrials.gov/show/NCT01504893	Completed	Azienda Ospedaliera S. Maria della Misericordia	2016-08-31
NCT01504867	LIPS-A: Lung Injury Prevention Study With Aspirin	https://ClinicalTrials.gov/show/NCT01504867	Completed	Mayo Clinic	2015-09-30
NCT01502332	Intensive Alveolar Recruitment Protocol After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01502332	Completed	University of Sao Paulo	2014-02-28
NCT01474863	Citrulline in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01474863	Completed	Vanderbilt University Medical Center	2016-03-31
NCT01438853	Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT01438853	Completed	Altor BioScience	2006-07-31
NCT01434121	Ascorbic Acid (Vitamin C) Infusion in Human Sepsis	https://ClinicalTrials.gov/show/NCT01434121	Completed	Virginia Commonwealth University	2012-09-30
NCT01427621	Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery	https://ClinicalTrials.gov/show/NCT01427621	Completed	Yonsei University	2010-11-30
NCT01344239	Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair	https://ClinicalTrials.gov/show/NCT01344239	Completed	First Affiliated Hospital, Sun Yat-Sen University	2011-05-31
NCT01335932	Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure	https://ClinicalTrials.gov/show/NCT01335932	Completed	Fred Hutchinson Cancer Research Center	2016-06-17
NCT01320384	Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)	https://ClinicalTrials.gov/show/NCT01320384	Completed	Poitiers University Hospital	2013-07-31
NCT04434001	ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery	https://ClinicalTrials.gov/show/NCT04434001	Recruiting	IRCCS Policlinico S. Donato	2020-08-10
NCT04412057	Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury	https://ClinicalTrials.gov/show/NCT04412057	Recruiting	Cerecor Inc	2020-10-31
NCT04402866	TD-0903 for ALI Associated With COVID-19	https://ClinicalTrials.gov/show/NCT04402866	Recruiting	Theravance Biopharma	2020-10-31
NCT04397510	Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury	https://ClinicalTrials.gov/show/NCT04397510	Enrolling by invitation	Frederick Health	2020-12-31
NCT04389840	Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure	https://ClinicalTrials.gov/show/NCT04389840	Recruiting	Chimerix	2021-02-28
NCT04375397	Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury	https://ClinicalTrials.gov/show/NCT04375397	Recruiting	AbbVie	2020-08-13
NCT04350736	First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19	https://ClinicalTrials.gov/show/NCT04350736	Recruiting	Theravance Biopharma	2020-06-30
NCT04341038	Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury	https://ClinicalTrials.gov/show/NCT04341038	Recruiting	Hospital Universitari de Bellvitge	2020-06-01
NCT04331613	Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS	https://ClinicalTrials.gov/show/NCT04331613	Recruiting	Chinese Academy of Sciences	2020-12-31
NCT04289324	Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants	https://ClinicalTrials.gov/show/NCT04289324	Recruiting	Medical University of Vienna	2022-06-30
NCT04133740	Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study	https://ClinicalTrials.gov/show/NCT04133740	Active, not recruiting	Aalborg University Hospital	2019-07-15
NCT03978845	Phrenic Nerve Block to Mitigate Self-inflicted Lung Injury	https://ClinicalTrials.gov/show/NCT03978845	Recruiting	University of Sao Paulo General Hospital	2019-12-31
NCT03960853	Effects of Different Ventilation Patterns on Lung Injury	https://ClinicalTrials.gov/show/NCT03960853	Recruiting	Sixth Affiliated Hospital, Sun Yat-sen University	2021-12-31
NCT03951064	Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon	https://ClinicalTrials.gov/show/NCT03951064	Enrolling by invitation	University of North Carolina, Chapel Hill	2021-06-30
NCT03905837	Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery	https://ClinicalTrials.gov/show/NCT03905837	Recruiting	Hospital General Universitario Gregorio Marañon	2021-05-28
NCT03902509	A Study About Safety and Efficacy of Pirfenidone to Treat Grade 2 or Grade3 Radiation-induced Lung Injury.	https://ClinicalTrials.gov/show/NCT03902509	Recruiting	Beijing Continent Pharmaceutical Co, Ltd.	2021-04-30
NCT03817918	A New Ultrasonographic Tool to Assess Pulmonary Strain in Patients Under One-lung Ventilation.	https://ClinicalTrials.gov/show/NCT03817918	Completed	Centre hospitalier de l’Université de Montréal (CHUM)	2019-05-17
NCT03764319	Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and VV-ECMO	https://ClinicalTrials.gov/show/NCT03764319	Recruiting	Medical University of Vienna	2020-05-06
NCT03753022	Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03753022	Active, not recruiting	Federal University of São Paulo	2019-12-31
NCT03719365	Driving Pressure Variation: NAVA vs PSV	https://ClinicalTrials.gov/show/NCT03719365	Recruiting	Azienda Ospedaliero Universitaria Maggiore della Carita	2019-12-01
NCT03659552	Percutaneous Temporary Placement of a Transvenous Phrenic Nerve Stimulator for Diaphragm Pacing Using Jugular Access	https://ClinicalTrials.gov/show/NCT03659552	Completed	Lungpacer Medical Inc.	2018-06-30
NCT03651817	Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg	https://ClinicalTrials.gov/show/NCT03651817	Completed	Kocaeli University	2019-11-20
NCT03637530	a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries	https://ClinicalTrials.gov/show/NCT03637530	Active, not recruiting	All India Institute of Medical Sciences, Rishikesh	2018-05-31
NCT03612583	Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work	https://ClinicalTrials.gov/show/NCT03612583	Recruiting	University Health Network, Toronto	2020-10-30
NCT03525691	Enhanced Lung Protective Ventilation With ECCO2R During ARDS	https://ClinicalTrials.gov/show/NCT03525691	Recruiting	Hôpital Européen Marseille	2020-12-30
NCT03464071	Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation	https://ClinicalTrials.gov/show/NCT03464071	Recruiting	Hospital de Clinicas de Porto Alegre	2019-09-10
NCT03437499	Adrenomedullin Changes After Sustained Inflation or Positive Pressure Ventilation at Birth	https://ClinicalTrials.gov/show/NCT03437499	Completed	Vittore Buzzi Children’s Hospital	2014-10-31
NCT03435913	Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery	https://ClinicalTrials.gov/show/NCT03435913	Completed	Hospital Universitario La Fe	2018-11-21
NCT01260259	Seattle Cardiorenal Remote Ischemic Preconditioning Trial	https://ClinicalTrials.gov/show/NCT01260259	Completed	Seattle Children’s Hospital	2013-08-31
NCT01194895	A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery	https://ClinicalTrials.gov/show/NCT01194895	Completed	Shanghai Zhongshan Hospital	2013-01-31
NCT01170845	Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy	https://ClinicalTrials.gov/show/NCT01170845	Completed	Yokohama City University Medical Center	2009-03-31
NCT01150864	Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial	https://ClinicalTrials.gov/show/NCT01150864	Completed	Università degli Studi dell’Insubria	2015-03-31
NCT01144585	Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass	https://ClinicalTrials.gov/show/NCT01144585	Completed	Seoul National University Hospital	2010-11-30
NCT01114009	Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients	https://ClinicalTrials.gov/show/NCT01114009	Completed	Chi Mei Medical Hospital	2011-12-31
NCT01050699	Sleep Intervention During Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01050699	Active, not recruiting	University of Arizona	2019-03-31
NCT00999713	CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients	https://ClinicalTrials.gov/show/NCT00999713	Completed	Milton S. Hershey Medical Center	2015-09-30
NCT00996840	SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS	https://ClinicalTrials.gov/show/NCT00996840	Completed	GlaxoSmithKline	2013-02-09
NCT00963066	NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00963066	Completed	University Hospital, Caen	2009-11-30
NCT00879606	Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT00879606	Completed	Altor BioScience	2012-10-31
NCT00852605	Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment	https://ClinicalTrials.gov/show/NCT00852605	Completed	Technische Universität Dresden	2005-08-31
NCT00830284	Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00830284	Completed	Boston Children’s Hospital	2012-12-31
NCT00883948	Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study)	https://ClinicalTrials.gov/show/NCT00883948	Completed	National Heart, Lung, and Blood Institute (NHLBI)	2011-03-31
NCT03092557	A New Ultrasonographic Tool to Assess Regional Pulmonary Strain	https://ClinicalTrials.gov/show/NCT03092557	Completed	Centre hospitalier de l’Université de Montréal (CHUM)	2017-10-26
NCT02978885	Imaging of Peri-operative (periOP) Lung Injury	https://ClinicalTrials.gov/show/NCT02978885	Recruiting	Columbia University	2020-09-30
NCT04351243	A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE).	https://ClinicalTrials.gov/show/NCT04351243	Recruiting	Kinevant Sciences GmbH	2020-10-31
NCT04311697	Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure	https://ClinicalTrials.gov/show/NCT04311697	Recruiting	NeuroRx, Inc.	2020-08-31
NCT00789685	Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II	https://ClinicalTrials.gov/show/NCT00789685	Completed	Faron Pharmaceuticals Ltd	2011-09-30
NCT00786292	Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00786292	Completed	Technische Universität Dresden	2012-09-30
NCT00747045	Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients	https://ClinicalTrials.gov/show/NCT00747045	Completed	University of California, San Diego	2011-03-31
NCT00655928	Modulation of Lung Injury Complicating Lung Resection	https://ClinicalTrials.gov/show/NCT00655928	Completed	Imperial College London	2009-07-31
NCT00624650	Hemodynamics and Extravascular Lung Water in Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00624650	Completed	Oregon Health and Science University	2011-01-31
NCT00568659	The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position	https://ClinicalTrials.gov/show/NCT00568659	Completed	Policlinico Hospital	2010-11-30
NCT00559130	Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis	https://ClinicalTrials.gov/show/NCT00559130	Completed	MedaSorb Technologies, Inc	2011-04-30
NCT00538161	Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient	https://ClinicalTrials.gov/show/NCT00538161	Completed	Beth Israel Deaconess Medical Center	2009-10-31
NCT00498251	Prevention of Lung Edema After Thoracic Surgery	https://ClinicalTrials.gov/show/NCT00498251	Completed	University Hospital, Geneva	NA
NCT00355875	The Effect of Oxygen Exposure During Newborn Resuscitation on Lung Injury	https://ClinicalTrials.gov/show/NCT00355875	Completed	University of Calgary	NA
NCT00351533	A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI)	https://ClinicalTrials.gov/show/NCT00351533	Completed	University of Washington	2009-01-31
NCT00290602	Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT00290602	Completed	National Cancer Center, Korea	NA
NCT00219375	Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan	https://ClinicalTrials.gov/show/NCT00219375	Completed	Ono Pharmaceutical Co. Ltd	2007-07-31
NCT00188058	Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT00188058	Completed	University Hospital, Angers	2006-01-31
NCT00143468	The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients	https://ClinicalTrials.gov/show/NCT00143468	Completed	Policlinico Hospital	2007-03-31
NCT00133614	Prone Positioning in Pediatric Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00133614	Completed	National Institute of Nursing Research (NINR)	NA
NCT00127491	Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00127491	Completed	Beth Israel Deaconess Medical Center	2007-08-31
NCT00036062	A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00036062	Completed	Eli Lilly and Company	NA
NCT00141726	Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant	https://ClinicalTrials.gov/show/NCT00141726	Completed	University of Michigan Rogel Cancer Center	2008-07-31

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03405779	A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU	https://ClinicalTrials.gov/show/NCT03405779	Recruiting	Centre hospitalier de l’Université de Montréal (CHUM)	2019-12-31
NCT03317431	the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury	https://ClinicalTrials.gov/show/NCT03317431	Completed	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	2017-10-22
NCT03315702	Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	https://ClinicalTrials.gov/show/NCT03315702	Completed	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	2017-10-15
NCT03135691	Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA	https://ClinicalTrials.gov/show/NCT03135691	Recruiting	Ohio State University	2020-12-31
NCT03076983	Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time	https://ClinicalTrials.gov/show/NCT03076983	Completed	Drägerwerk AG & Co. KGaA	2018-04-12
NCT02977676	Ventilator-Associated Events: Prevalence, Outcome and Preventability	https://ClinicalTrials.gov/show/NCT02977676	Completed	Hospital Sao Domingos	2016-01-31
NCT02732041	Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT02732041	Completed	Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno	2018-11-22
NCT02475694	Acute Lung Injury After Cardiac Surgery: Pathogenesis	https://ClinicalTrials.gov/show/NCT02475694	Completed	Aalborg University Hospital	2009-03-31
NCT02299921	Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure	https://ClinicalTrials.gov/show/NCT02299921	Active, not recruiting	University of Colorado, Denver	2022-02-28
NCT02247700	Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography	https://ClinicalTrials.gov/show/NCT02247700	Completed	Boston Children’s Hospital	2018-11-04
NCT02201446	The Role of Circulating Soluble CD74 in Acute Lung Injury	https://ClinicalTrials.gov/show/NCT02201446	Completed	Changhai Hospital	2014-11-30
NCT02174029	Serial Daily Diaphragm Ultrasounds in Ventilated Patients	https://ClinicalTrials.gov/show/NCT02174029	Completed	Fraser Health	2014-08-31
NCT02083393	Changes of Dendritic Cells in Acute Lung Injury	https://ClinicalTrials.gov/show/NCT02083393	Completed	Southeast University, China	2014-12-31
NCT01270295	Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE).	https://ClinicalTrials.gov/show/NCT01270295	Completed	University Hospital, Clermont-Ferrand	2013-01-31
NCT04262440	The Effect of Caloric Supplement in the Clinical Outcomes in Acute Lung Injury Patients	https://ClinicalTrials.gov/show/NCT04262440	Recruiting	Taichung Veterans General Hospital	2022-12-31
NCT01628523	Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study	https://ClinicalTrials.gov/show/NCT01628523	Completed	Washington University School of Medicine	2013-08-31
NCT01601223	Local Assessment of Ventilatory Management During General Anesthesia for Surgery	https://ClinicalTrials.gov/show/NCT01601223	Completed	European Society of Anaesthesiology	2013-05-31
NCT01486342	PET Imaging in Patients at Risk for Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01486342	Completed	Washington University School of Medicine	2012-10-31
NCT01322295	Human Bronchial Microdialysis in Open Aortic Aneurysm Repair	https://ClinicalTrials.gov/show/NCT01322295	Completed	Norwegian University of Science and Technology	2011-11-30
NCT01321398	Transpulmonary Pressure Gradients in High Frequency Oscillation	https://ClinicalTrials.gov/show/NCT01321398	Completed	University of British Columbia	2011-07-31
NCT04395482	Lung CT Scan Analysis of SARS-CoV2 Induced Lung Injury	https://ClinicalTrials.gov/show/NCT04395482	Recruiting	University of Milano Bicocca	2020-06-15
NCT04046380	A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies	https://ClinicalTrials.gov/show/NCT04046380	Recruiting	Changhua Christian Hospital	2021-06-30
NCT04030078	A Central and Eastern European Survey On PEEP Titration and Alveolar Recruitment Manoeuvres During Surgery	https://ClinicalTrials.gov/show/NCT04030078	Completed	Péterfy Sándor Hospital	2019-09-30
NCT03947476	Extrapulmonary Lung Protection Strategy for Patients With Mechanical Ventilation	https://ClinicalTrials.gov/show/NCT03947476	Recruiting	Shanghai Zhongshan Hospital	2021-08-01
NCT03945409	New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure	https://ClinicalTrials.gov/show/NCT03945409	Recruiting	University of Milan	2020-03-31
NCT03937947	Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study	https://ClinicalTrials.gov/show/NCT03937947	Recruiting	NHS Lothian	2020-10-31
NCT03924206	Hazardous Surgical Smoke: Risk Assessment and Evaluation of a New Smoke Extractor System in the Surgical Unit	https://ClinicalTrials.gov/show/NCT03924206	Completed	University Hospital Inselspital, Berne	2019-09-09
NCT03828630	Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients	https://ClinicalTrials.gov/show/NCT03828630	Completed	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2019-02-27
NCT03766204	The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury	https://ClinicalTrials.gov/show/NCT03766204	Recruiting	Changhai Hospital	2023-12-31
NCT03746236	Transpulmonary Pressure Under Stressing Conditions	https://ClinicalTrials.gov/show/NCT03746236	Recruiting	Regina Elena Cancer Institute	2019-12-30
NCT03654352	The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT03654352	Recruiting	University of Kentucky	2020-12-31
NCT03431129	Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation	https://ClinicalTrials.gov/show/NCT03431129	Recruiting	The Hospital for Sick Children	2020-11-30
NCT01187004	Extracardiac Complications After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT01187004	Completed	University of Turin, Italy	2008-12-31
NCT01159392	Alveolar Recruitment in Brain Injury	https://ClinicalTrials.gov/show/NCT01159392	Completed	Hospital Clinic of Barcelona	NA
NCT01142544	Incidence of Acute Lung Injury in Children	https://ClinicalTrials.gov/show/NCT01142544	Completed	Dr. Negrin University Hospital	2011-02-28
NCT01105663	Pharmacologic Impact on Sedation Assessments	https://ClinicalTrials.gov/show/NCT01105663	Completed	Children’s Hospital of Philadelphia	2013-12-31
NCT01089400	Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage	https://ClinicalTrials.gov/show/NCT01089400	Completed	Institut National de la Santé Et de la Recherche Médicale, France	NA
NCT01078831	Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy	https://ClinicalTrials.gov/show/NCT01078831	Completed	Oslo University Hospital	2010-04-30
NCT00980915	Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00980915	Active, not recruiting	Mayo Clinic	2020-12-31
NCT00889772	Lung Injury Prediction Study	https://ClinicalTrials.gov/show/NCT00889772	Completed	Mayo Clinic	2010-02-28
NCT00826072	Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT00826072	Completed	Changhai Hospital	2008-11-30
NCT00825357	Biological Markers to Identify Early Sepsis and Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00825357	Completed	Chimei Medical Center	2011-08-31
NCT04449081	Knowledge, Attitude and Practice of Dental Students About COVID-19	https://ClinicalTrials.gov/show/NCT04449081	Completed	Melaka Manipal Medical College	2020-06-10
NCT00811629	Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients	https://ClinicalTrials.gov/show/NCT00811629	Completed	University Hospital, Clermont-Ferrand	2009-07-31
NCT01922557	Thoracic Fluid Content and Acute Lung Injury	https://ClinicalTrials.gov/show/NCT01922557	Completed	National Taiwan University Hospital	2011-01-31
NCT03709199	Long Term Follow up of Children Enrolled in the REDvent Study	https://ClinicalTrials.gov/show/NCT03709199	Recruiting	Children’s Hospital Los Angeles	2023-01-01
NCT02739438	The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction	https://ClinicalTrials.gov/show/NCT02739438	Recruiting	Queen’s University, Belfast	2019-12-31
NCT02549222	A Open Label, Post Marketing Surveillance Study Following Transfusion of INTERCEPT Platelet Components	https://ClinicalTrials.gov/show/NCT02549222	Enrolling by invitation	Cerus Corporation	2020-09-30
NCT00736892	Incidence of Acute Lung Injury: The Alien Study	https://ClinicalTrials.gov/show/NCT00736892	Completed	Villar, Jesus, M.D.	2010-03-31
NCT00682942	How to Predict Lung Recruitment at the Bedside in Patients Affected by Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS)	https://ClinicalTrials.gov/show/NCT00682942	Completed	Policlinico Hospital	2011-06-30
NCT00673517	The Effect of High Frequency Oscillation on Biological Markers of Lung Injury	https://ClinicalTrials.gov/show/NCT00673517	Completed	St. Michael’s Hospital, Toronto	2008-11-30
NCT00659152	Morphofunctional Lung Analysis by Positron Emission Tomography	https://ClinicalTrials.gov/show/NCT00659152	Completed	Policlinico Hospital	2013-12-31
NCT00521625	Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury	https://ClinicalTrials.gov/show/NCT00521625	Completed	St. Justine’s Hospital	NA
NCT00435110	Effects of PEEP and FIO2 in ALI and ARDS	https://ClinicalTrials.gov/show/NCT00435110	Completed	Instituto Canario de Investigacion Biomedica	NA
NCT00819871	Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT00819871	Completed	Changhai Hospital	2008-10-31
NCT00300248	Long-Term Results in Mechanically Ventilated Individuals With Acute Lung Injury/Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT00300248	Completed	Johns Hopkins University	2012-10-31
NCT00258518	Respiratory Mechanics and Pleural Effusion	https://ClinicalTrials.gov/show/NCT00258518	Completed	Policlinico Hospital	2011-06-30
NCT00234767	Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT00234767	Completed	University of Pittsburgh	2007-08-31

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02613377	Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children	https://ClinicalTrials.gov/show/NCT02613377	Active, not recruiting	St. Justine’s Hospital	2020-01-31
NCT02320539	MicroRNA Diagnostics in Subarachnoid Hemorrhage 2	https://ClinicalTrials.gov/show/NCT02320539	Completed	Rigshospitalet, Denmark	2015-05-31
NCT03581006	Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment, and Dietary Intervention	https://ClinicalTrials.gov/show/NCT03581006	Recruiting	NYU Langone Health	2021-09-30
NCT03513809	Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients	https://ClinicalTrials.gov/show/NCT03513809	Recruiting	Pontificia Universidad Catolica de Chile	2021-06-08